Small nuclear ribonucleoprotein D2

Small nuclear ribonucleoprotein D2 polypeptide 16.5kDa

PDB rendering based on 1b34.

Available structures
PDB	1B34, 3CW1

Identifiers

Symbols

SNRPD2; SMD2; SNRPD1; Sm-D2

External IDs

OMIM: 601061 MGI: 98345 HomoloGene: 3381 GeneCards: SNRPD2 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• nucleus • nucleoplasm • nucleoplasm • spliceosomal complex • U12-type spliceosomal complex • cytosol • cytosol • small nuclear ribonucleoprotein complex • catalytic step 2 spliceosome
Biological process	• spliceosome assembly • spliceosomal snRNP assembly • nuclear mRNA splicing, via spliceosome • nuclear mRNA splicing, via spliceosome • RNA splicing • gene expression • RNA metabolic process • ncRNA metabolic process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
46.19 – 46.2 Mb

Chr 7:
19.74 – 19.74 Mb

PubMed search

[1]

[2]

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene.^[1]^[2]^[3]

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.^[3]

Interactions

Small nuclear ribonucleoprotein D2 has been shown to interact with DDX20,^[4] Small nuclear ribonucleoprotein D1,^[5]^[6] Small nuclear ribonucleoprotein polypeptide F,^[5] CDC5L^[7] and SMN1.^[8]

References

^ Lehmeier T, Raker V, Hermann H, Luhrmann R (Jan 1995). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction". Proc Natl Acad Sci U S A 91 (25): 12317–21. doi:10.1073/pnas.91.25.12317. PMC 45428. PMID 7527560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=45428.
^ Lehmeier T, Foulaki K, Luhrmann R (Jan 1991). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5". Nucleic Acids Res 18 (22): 6475–84. doi:10.1093/nar/18.22.6475. PMC 332598. PMID 1701240. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=332598.
^ ^a ^b "Entrez Gene: SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6633.
^ Charroux, B; Pellizzoni L, Perkinson R A, Shevchenko A, Mann M, Dreyfuss G (Dec. 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. (UNITED STATES) 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. ISSN 0021-9525. PMC 2168095. PMID 10601333. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2168095.
^ ^a ^b Fury, M G; Zhang W, Christodoulopoulos I, Zieve G W (Nov. 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. (UNITED STATES) 237 (1): 63–9. doi:10.1006/excr.1997.3750. ISSN 0014-4827. PMID 9417867.
^ Kambach, C; Walke S, Young R, Avis J M, de la Fortelle E, Raker V A, Lührmann R, Li J, Nagai K (Feb. 1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell (UNITED STATES) 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. ISSN 0092-8674. PMID 10025403.
^ Ajuh, P; Kuster B, Panov K, Zomerdijk J C, Mann M, Lamond A I (Dec. 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305846.
^ Meister, G; Bühler D, Laggerbauer B, Zobawa M, Lottspeich F, Fischer U (Aug. 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. (ENGLAND) 9 (13): 1977–86. doi:10.1093/hmg/9.13.1977. ISSN 0964-6906. PMID 10942426.

Rokeach LA, Haselby JA, Hoch SO (1988). "Molecular cloning of a cDNA encoding the human Sm-D autoantigen.". Proc. Natl. Acad. Sci. U.S.A. 85 (13): 4832–6. doi:10.1073/pnas.85.13.4832. PMC 280530. PMID 3260384. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=280530.
Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins.". Cell 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129.
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins.". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
Kambach C, Walke S, Young R, et al. (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.". Cell 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. PMID 10025403.
Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems.". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2168095.
Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli.". J. Cell Biol. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174312.
Meister G, Bühler D, Laggerbauer B, et al. (2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins.". Hum. Mol. Genet. 9 (13): 1977–86. doi:10.1093/hmg/9.13.1977. PMID 10942426.
Ajuh P, Kuster B, Panov K, et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305846.
Selenko P, Sprangers R, Stier G, et al. (2001). "SMN tudor domain structure and its interaction with the Sm proteins.". Nat. Struct. Biol. 8 (1): 27–31. doi:10.1038/83014. PMID 11135666.
Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure.". EMBO J. 20 (1-2): 187–96. doi:10.1093/emboj/20.1.187. PMC 140196. PMID 11226169. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=140196.
Gubitz AK, Mourelatos Z, Abel L, et al. (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins.". J. Biol. Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.
Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component.". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
Friesen WJ, Wyce A, Paushkin S, et al. (2002). "A novel WD repeat protein component of the methylosome binds Sm proteins.". J. Biol. Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation.". Nature 414 (6866): 929–33. doi:10.1038/414929a. PMID 11780068.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370266.
Baccon J, Pellizzoni L, Rappsilber J, et al. (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex.". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Blagoev B, Kratchmarova I, Ong SE, et al. (2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling.". Nat. Biotechnol. 21 (3): 315–8. doi:10.1038/nbt790. PMID 12577067.

PDB gallery

1b34: CRYSTAL STRUCTURE OF THE D1D2 SUB-COMPLEX FROM THE HUMAN SNRNP CORE DOMAIN

RNA-binding protein: Ribonucleoproteins

snRNP	A · A1 · B · B2 · C · D1 · D2 · D3 · E · F · G · N 70K/U1 spliceosomal RNA SNRNP200

hnRNP	A0 · C · L · R

Other transcription	Telomerase

Translation	Ribosome

Vault ribonucleoprotein particles	Major vault protein

Other	Signal recognition particle

B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

Small nuclear ribonucleoprotein D2

Interactions

References

Further reading